{"id":108755,"date":"2019-08-26T11:00:39","date_gmt":"2019-08-26T15:00:39","guid":{"rendered":"https:\/\/madisoncountycourier.com\/?p=108755"},"modified":"2019-08-26T11:00:39","modified_gmt":"2019-08-26T15:00:39","slug":"childhood-cancer-survivors-at-elevated-risk-of-heart-disease","status":"publish","type":"post","link":"https:\/\/madisoncountycourier.com\/?p=108755","title":{"rendered":"Childhood cancer survivors at elevated risk of heart disease"},"content":{"rendered":"\n
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Survivors of childhood cancer have a higher risk of\ndeveloping a range of heart disease due to cancer therapy, according to new\nresearch published in the American Heart Association\u2019s journal Circulation.<\/p>\n\n\n\n

Most studies of this survivor group have focused on heart\nfailure related to anthracyclines, a class of chemotherapy medications used to\ntreat many types of cancer. In this new study, researchers used data from\nOntario\u2019s health care system to investigate the full spectrum of heart disease\nsubtypes in close to 7,300 childhood cancer survivors (diagnosed at an average\nage of 7) \u2013 compared to more than 36,000 people of the same age, gender and\npostal code without cancer. Heart disease studied included coronary artery\ndisease, arrhythmias, valve abnormalities, cardiomyopathy, heart failure and\npericardial disease. <\/p>\n\n\n\n

Researchers found that, even at relatively young ages,\nchildhood cancer survivors have up to a threefold increase for any cardiac\nevent and up to a tenfold increased risk for heart failure when compared to\ntheir cancer-free peers. Additionally, survivors exposed to higher doses of\nanthracycline chemotherapy, as well as those diagnosed with diabetes,\nhypertension or both, are significantly more likely to experience heart disease\nas adults.<\/p>\n\n\n\n

\u201cWhile anthracycline chemotherapy may induce heart disease,\nmany patients require this cancer treatment to survive,\u201d said Paul Nathan,\nM.D., M.Sc., senior author of the study and staff oncologist in the division of\nhematology\/oncology and senior associate scientist in the Child Health\nEvaluative Sciences program at The Hospital for Sick Children (SickKids) in\nCanada.<\/p>\n\n\n\n

\u201cDoctors should address heart disease risk factors \u2013 such as\ndiabetes and hypertension \u2013 that can be modified,\u201d said Nathan, who is also a\nprofessor in the pediatrics and health policy, management and evaluation\ndepartments at the University of Toronto.<\/p>\n\n\n\n

Childhood cancer survivors appear to have a higher\nlikelihood of metabolic conditions such as diabetes, hypertension and unhealthy\nlevels of one or more kinds of lipid (fat) in the blood. These modifiable risk\nfactors appear to interact with chemotherapy or radiation that may be toxic to\nthe heart, prematurely age the heart and accelerate the development of heart\ndisease.<\/p>\n\n\n\n

\u201cThe close connections between lifestyle, metabolic\ndisorders and cardiac disease warrant careful follow-up and monitoring of the\nchildhood cancer survivor population,\u201d Nathan said.<\/p>\n\n\n\n

Researchers used the Pediatric Oncology Group of Ontario\nNetworked Information System, a provincial pediatric cancer registry, to\nidentify five-year cancer survivors who were diagnosed before age 18 and\ntreated in a pediatric cancer center between 1987 and 2010. Each childhood\ncancer survivor was matched to five cancer-free peers for the purposes of this\ncomparative study. During an average of 10 years of follow-up, nearly 3 percent\nof childhood cancer survivors experienced one or more cardiac events, compared\nto less than 1 percent of those without cancer.<\/p>\n\n\n\n

Researchers were unable to assess lifestyle factors such as\nsmoking, physical activity, diet and alcohol use. A more comprehensive\nunderstanding of these and other modifiable factors and their impact on\ncardiovascular disease among childhood cancer survivors could be gained through\nfuture work involving the use of data from multiple sources.<\/p>\n\n\n\n

Co-authors are Ashna Khanna, M.Sc.; Priscila Pequeno, MSc;\nSumit Gupta, M.D., Ph.D.; Paaladinesh Thavendiranathan, M.D., M.Sc.; Douglas\nLee, D.S., M.D., Ph.D.; and Husam Abdel-Qadir, M.D., Ph.D. Author disclosures\nare in the manuscript.<\/p>\n\n\n\n

Canadian Institutes for Health Research, SickKids Research\nTraining Competition, the Heart and Stroke Foundation, and the Ted Rogers Chair\nin Heart Function Outcomes (a joint Hospital-University Chair of the University\nHealth Network and the University of Toronto) funded the study.<\/p>\n","protected":false},"excerpt":{"rendered":"

Survivors of childhood cancer have a higher risk of developing a range of heart disease due to cancer therapy, according to new research published in the American Heart Association\u2019s journal Circulation. Most studies of this survivor group have focused on heart failure related to anthracyclines, a class of chemotherapy medications used to treat many types […]<\/p>\n","protected":false},"author":2,"featured_media":97983,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[23810,8],"tags":[],"class_list":["post-108755","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-wellbeing","category-top-story"],"_links":{"self":[{"href":"https:\/\/madisoncountycourier.com\/index.php?rest_route=\/wp\/v2\/posts\/108755","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/madisoncountycourier.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/madisoncountycourier.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/madisoncountycourier.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/madisoncountycourier.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=108755"}],"version-history":[{"count":0,"href":"https:\/\/madisoncountycourier.com\/index.php?rest_route=\/wp\/v2\/posts\/108755\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/madisoncountycourier.com\/index.php?rest_route=\/wp\/v2\/media\/97983"}],"wp:attachment":[{"href":"https:\/\/madisoncountycourier.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=108755"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/madisoncountycourier.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=108755"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/madisoncountycourier.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=108755"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}